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In ALS models, SOD1 mutations do not markedly alter astrocytic baseline states but lower the threshold for reactivity, which sensitizes astrocytes to oxidative, glutamatergic and inflammatory stress and drives exaggerated reactive responses to otherwise moderate insults 80

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Inflammation occurring when the immune system Immune system The bodys defense mechanism against foreign organisms or substances and deviant native cells

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Initial lightening becomes visible within 2-4 weeks, with progressive improvement throughout the treatment period